Providing Comorbid Decision Support via the Integration of Clinical Practice Guidelines at Execution-Time by...

Clinical Decision Support Systems (CDSS) utilize computerized Clinical Practice Guidelines (CPG) to deliver evidence-based care recommendations. However, when dealing with comorbidity (i.e., patients with multiple conditions), disease-specific CPG often interact in adverse ways (e.g., drug-drug, drug-disease interactions), and may involve redundant elements as well (e.g., repeated care tasks). To avoid adverse interactions and optimize care, current options involve the static, a priori integration of comorbid CPG by replacing or removing therapeutic tasks. Nevertheless, many aspects are relevant to a clinically safe and efficient integration, and these may change over time-task delays, test outcomes, and health profiles-which are not taken into account by static integrations. Moreover, in case of comorbidity, clinical practice often demands nuanced solutions, based on current health profiles. We propose an execution-time approach to safely and efficiently cope with comorbid conditions, leveraging knowledge from medical Linked Open Datasets to aid during CIG integration.