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Updated: Jan 20, 2026

Measuring Attentional Biases for Threat in Children and Adults
Published on: October 19, 2014
Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use
Liangsuo Ma1, Joel L Steinberg2, James M Bjork2
1Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA; Department of Radiology, Virginia Commonwealth University, Richmond, VA, USA.
Abstract:
Individuals with opioid use disorder (OUD) often relapse when exposed to opioid-related cues. Previous functional magnetic resonance imaging (fMRI) studies have identified neuronal corticolimbic changes related to drug cue reactivity in OUD. However, the corresponding manner in which brain regions interact is still unclear. Effective (directional) connectivity was analyzed using dynamic causal modeling of fMRI data acquired from 27 OUD participants (13 with OUD and 14 with OUD and cocaine use disorder [OUD+CUD]), while performing an opioid-word Stroop task. Participants were shown opioid and neutral words presented in different colors and were instructed to indicate word color but ignore word meaning. The effects of opioid words relative to neutral words on effective connectivity and on behavioral reaction time were defined as modulatory change and attentional bias, respectively. For all the 27 participants, left anterior cingulate cortex (ACC) to right hippocampus effective connectivity exhibited the largest modulatory change, which was positively correlated with attentional bias. The findings for the ACC to hippocampus EC were consistent across OUD and CUD found in a previous study.
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