Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.4K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.4K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.5K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.5K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.5K
3.5K
Deformation in a Circular Shaft01:10

Deformation in a Circular Shaft

876
One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...
876
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.3K
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel Upward-Extended Five-Zone model for overburden failure in deep coal seams with ultra-thick Cretaceous strata.

Scientific reports·2026
Same author

Karyotype-specific cardiovascular and metabolic profiles in Turner syndrome: a retrospective echocardiographic study.

Orphanet journal of rare diseases·2026
Same author

The miR-4512/PDZK1IP1 axis in hepatocellular carcinoma: clinical significance, diagnostic value, and functional validation.

BMC medical genomics·2026
Same author

Integrative machine learning and multi-omics analysis reveals ATIC as a promoter of hepatocellular carcinoma progression.

Scientific reports·2026
Same author

Garcinol Inhibits the Proliferation of Endometriosis Cells by Regulating Cell Cycle Related Genes and Signaling Pathways.

Molecular reproduction and development·2026
Same author

Editorial: The state of placental research in China.

Placenta·2026

Related Experiment Video

Updated: Jan 20, 2026

Quantification of Circular RNAs Using Digital Droplet PCR
08:39

Quantification of Circular RNAs Using Digital Droplet PCR

Published on: September 16, 2022

4.0K

[Research advance in circular RNAs].

Yu-Han Qi1, Ze-Peng Liu1, Wei-Jie Zhang1

  • 1School of Stomatology, Tongji University, Shanghai 200092, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|August 24, 2019
PubMed
Summary

Circular RNAs (circRNAs) are unique RNA molecules regulating gene expression and protein translation. This review covers their biogenesis, functions, disease associations, and future research directions.

More Related Videos

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.7K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.7K

Related Experiment Videos

Last Updated: Jan 20, 2026

Quantification of Circular RNAs Using Digital Droplet PCR
08:39

Quantification of Circular RNAs Using Digital Droplet PCR

Published on: September 16, 2022

4.0K
Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.7K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.7K

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are non-linear RNA molecules with unique structural features.
  • They play crucial roles in regulating gene expression and protein synthesis.
  • circRNAs are conserved across species and exhibit diverse functions.

Purpose of the Study:

  • To provide a comprehensive overview of circular RNAs (circRNAs).
  • To summarize the current understanding of circRNA biogenesis, classification, and function.
  • To discuss the role of circRNAs in diseases and their potential applications.

Main Methods:

  • Literature review and synthesis of existing research on circRNAs.
  • Analysis of circRNA biogenesis pathways and regulatory mechanisms.
  • Discussion of methods for circRNA identification and characterization.

Main Results:

  • circRNAs are universally expressed, diverse, stable, and conserved RNA molecules.
  • They regulate mammalian transcription and can be translated into proteins.
  • circRNAs are implicated in various human diseases.

Conclusions:

  • circRNAs represent a significant class of regulatory RNAs with broad biological functions.
  • Understanding circRNAs is crucial for developing novel diagnostic and therapeutic strategies.
  • Further research into circRNA applications and mechanisms is warranted.