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Updated version of Japanese Childhood Health Assessment Questionnaire (CHAQ)

Takako Miyamae1,2, Yumi Tani1,2, Takayuki Kishi1,2

  • 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.

Modern Rheumatology
|August 24, 2019
PubMed

Insights

The revised Japanese Childhood Health Assessment Questionnaire (JCHAQ) is a reliable tool for assessing functional status in Juvenile idiopathic arthritis (JIA). This updated JCHAQ is suitable for international comparisons in clinical trials.

Area of Science:

  • Pediatric Rheumatology
  • Clinical Assessment Tools
  • Health Outcomes Research

Background:

  • The Childhood Health Assessment Questionnaire (CHAQ) is a key self-report measure for functional status in Juvenile idiopathic arthritis (JIA).
  • International clinical trials require standardized assessment tools, necessitating revisions to existing instruments like the Japanese CHAQ (JCHAQ).

Purpose of the Study:

  • To revise and validate the Japanese version of the CHAQ (JCHAQ) to align with international clinical trial requirements.
  • To ensure each functional area in the JCHAQ has an equivalent number of questions to the original US English CHAQ.

Main Methods:

  • The JCHAQ was revised from 36 items to 30 items, standardizing the number of questions per functional area.
  • Professional translation from English to Japanese, followed by review and validation in a cohort of Japanese JIA patients.

Main Results:

  • Validation involved 42 JIA patients across different subtypes (systemic, polyarticular/oligoarticular, enthesis related).
  • The revised JCHAQ demonstrated significant correlations with pain, well-being, physician assessments, DAS28-ESR, and JADAS-27.
  • Disease activity scores (DAS28-ESR and JADAS-27) significantly correlated with the Disability Index (DI) in patients with moderate/high disease activity.

Conclusions:

  • The updated JCHAQ is a reliable and valid instrument for functional assessment in children with JIA.
  • The revised JCHAQ is better suited for international comparisons and transitional studies in JIA research.

Keywords:
Childhood Health Assessment Questionnaire (CHAQ)health-related quality of lifejuvenile idiopathic arthritis (JIA)questionnaire

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