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Kelch-like proteins: Physiological functions and relationships with diseases

Xiaoxian Shi1, Senfeng Xiang1, Ji Cao1

  • 1Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

Pharmacological Research
|August 24, 2019
PubMed
Summary

Kelch-like gene family proteins (KLHLs) form E3 ligase complexes, crucial for protein ubiquitination. Dysregulation of KLHLs is linked to various human diseases, highlighting their pathogenic roles.

Keywords:
CancerChronic dieasesDimethyl fumarate (PubChem CID: 637568)E3 ligaseHereditary diseasesKLHLsML334/LH601A (PubChem CID: 56840728)Nutlin-3A (PubChem CID: 11433190)SubstrateUbiquitination

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