Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

43.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.2K
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

1.3K
At room temperature, the chair conformer of cyclohexane undergoes rapid ring flipping between two equivalent chair conformers at a rate of approximately 105 times per second. These two chair conformers are in equilibrium. The rapid ring flipping results in the interconversion of the axial proton to an equatorial proton and an equatorial to the axial proton. Such interconversions are too rapid and cannot be detected on the NMR timescale. Hence, the NMR spectrometer cannot distinguish between the...
1.3K
Labeling DNA Probes03:31

Labeling DNA Probes

9.3K
DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
9.3K
Neural Circuits01:25

Neural Circuits

2.7K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
2.7K
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR01:15

¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR

1.7K
The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.
1.7K
Neural Control of Respiration01:18

Neural Control of Respiration

4.6K
The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Impurities on Direct Recycling of Spent LiNi<sub><i>x</i></sub>Co<sub><i>y</i></sub>Mn<sub><i>z</i></sub>O<sub>2</sub> Cathode Material for Lithium-Ion Batteries.

ACS nano·2026
Same author

Friend, Not Foe: Lowered Tissue Reactivity to Long-Term Polyimide Implants.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Friend, not Foe: Lowered Tissue Reactivity to Long-Term Polyimide Implants.

bioRxiv : the preprint server for biology·2026
Same author

Dibenzazepine Bridged Network Polymeric Phthalocyanines as Degradable Heterogeneous Photocatalysts.

Angewandte Chemie (International ed. in English)·2026
Same author

Efficient and sustained optogenetic control of sensory and cardiac systems.

Nature biomedical engineering·2025
Same author

Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system.

Journal of neural engineering·2025

Related Experiment Video

Updated: Jan 20, 2026

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
06:40

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

15.3K

CMOS-Compatible, Flexible, Intracortical Neural Probes.

Falk Barz, Vanessa Trouillet, Oliver Paul

    IEEE Transactions on Bio-Medical Engineering
    |August 24, 2019
    PubMed
    Summary

    This study developed novel flexible neural probes integrating complementary metal-oxide-semiconductor (CMOS) technology for enhanced brain recording. These probes combine flexibility with high-density recording capabilities, overcoming limitations of existing rigid and flexible designs.

    More Related Videos

    Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
    06:39

    Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

    Published on: June 8, 2022

    2.8K
    Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
    09:48

    Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

    Published on: September 11, 2017

    10.3K

    Related Experiment Videos

    Last Updated: Jan 20, 2026

    Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive
    06:40

    Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

    Published on: September 27, 2013

    15.3K
    Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes
    06:39

    Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes

    Published on: June 8, 2022

    2.8K
    Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
    09:48

    Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

    Published on: September 11, 2017

    10.3K

    Area of Science:

    • Neuroscience
    • Materials Science
    • Electrical Engineering

    Background:

    • Flexible neural probes reduce foreign body response compared to rigid implants.
    • Complementary metal-oxide-semiconductor (CMOS) technology offers scalability and advanced functionalities for neural probes.

    Purpose of the Study:

    • To develop a novel neural probe combining probe flexibility with the functionalities of active CMOS-based probes.
    • To create a new generation of neural probes for advanced brain-computer interfaces.

    Main Methods:

    • Interfacing short CMOS-based probe tips with flexible polyimide cables for full brain tissue implantation.
    • Utilizing a novel combination of ion beam and plasma etching for multilayer platinum metallization of flexible cables.
    • Employing stiff insertion shuttles for probe implantation in brain models.

    Main Results:

    • Assembled neural probes with active tips as short as 1.5 mm and width <180 μm, featuring 72 recording sites and multiplexing to 16 lines.
    • Achieved reliable patterning of signal lines (2 μm width, 3 μm spacing) on cables.
    • Successfully implanted probes to 7 mm depth, withstanding forces of 63 mN, and restored insulation resistance via plasma treatment.

    Conclusions:

    • Presented methods for fabricating and applying a new generation of neural probes.
    • Demonstrated a synergetic approach overcoming limitations of individual probe technologies for future development.