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Updated: Jan 20, 2026
07:35
Non-chromatographic Purification of Recombinant Elastin-like Polypeptides and their Fusions with Peptides and Proteins from Escherichia coli
Published on: June 9, 2014
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pH-Responsive Polypeptide-Based Smart Nano-Carriers for Theranostic Applications.
Rimesh Augustine1, Nagendra Kalva1, Ho An Kim1
1BK 21 PLUS Center for Advanced Chemical Technology, Department of Polymer Science and Engineering, Pusan National University, Geumjeong-gu, Busan 46241, Korea.
Molecules (Basel, Switzerland)
|August 25, 2019
Summary
Smart nano-carriers offer targeted drug delivery by responding to pH changes, crucial for effective cancer therapy. This review focuses on pH-responsive polypeptides and nanocarrier designs for enhanced theranostic applications.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Smart nano-carriers are vital in biomedicine, evolving from basic loading efficiency to complex targeted and stimuli-responsive systems.
- Biocompatibility, efficacy, and reduced side effects are key drivers in nanocarrier development.
- Stimuli-responsive polymers enable controlled drug release at targeted sites.
Purpose of the Study:
- To review pH-responsive polypeptides and nanocarrier designs for theranostic applications.
- To emphasize pharmaceutical applications of nanocarriers across different physiological pH environments.
- To highlight the precision of pH-triggered release in organ, tissue, and cellular contexts.
Main Methods:
- Focus on pH-responsive polypeptides and their role in nanocarrier design.
- Analysis of nanocarrier functionalities for targeted and stimuli-responsive drug delivery.
- Exploration of pH-dependent morphology changes in polymers for controlled release.
Main Results:
- pH-triggered release is increasingly important due to acidic environments in organs and cancer cells.
- Polymers with pH-dependent characteristics enable precise guest molecule release.
- Theranostic applications are enhanced by targeted delivery and stimuli-responsive release.
Conclusions:
- pH-responsive polypeptides are promising for advanced nanocarrier systems.
- Targeted and stimuli-responsive nanocarriers improve therapeutic efficacy and reduce side effects.
- Understanding physiological pH variations is critical for optimizing nanocarrier performance in theranostics.
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