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Expression of THSD7A in neoplasm tissues and its relationship with proteinuria

Li Xian1, Dandan Dong2, Jiamei Luo1

  • 1Renal Division and Institute of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West 2nd Duan, 1st Circle Road, Qingyang District, Chengdu, Sichuan, People's Republic of China, 610072.

BMC Nephrology
|August 25, 2019
PubMed
Abstract

Insights

Thrombospondin type 1 domain containing 7A (THSD7A) is highly expressed in colorectal and breast cancers. This finding suggests THSD7A may link malignancies to kidney diseases like membranous nephropathy.

Area of Science:

  • Oncology
  • Nephrology
  • Immunology

Background:

  • Thrombospondin type 1 domain containing 7A (THSD7A) is a target autoantigen in membranous nephropathy (MN).
  • THSD7A expression is linked to malignancies and found in various tumors.
  • Investigating THSD7A in cancer and its relation to proteinuria is crucial.

Purpose of the Study:

  • To examine THSD7A expression in colorectal and breast cancers.
  • To determine the association between THSD7A expression and proteinuria in cancer patients.

Main Methods:

  • 101 cancer patients (81 colorectal, 20 breast) were studied.
  • Immunohistochemical staining assessed THSD7A expression in tumor tissues.
  • Clinical and laboratory data were collected pre-surgery.

Main Results:

  • THSD7A expression was highly prevalent: 97.5% in colorectal cancer, 100% in breast cancer.
  • Positive THSD7A was found in lymph nodes of patients with metastasis.
  • 10.9% of patients had proteinuria, which resolved post-surgery in 3 of 4 cases.

Conclusions:

  • High THSD7A expression is characteristic of colorectal and breast cancers.
  • THSD7A may represent a significant link between cancer and kidney disease.
Keywords:
Breast cancerColorectal cancerMembranous nephropathyProteinuriaThrombospondin type 1 domain containing 7A

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