Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:19

Cell Migration

6.4K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.4K
Cell Migration01:09

Cell Migration

18.7K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.7K
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

3.3K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
3.3K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.2K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.2K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.2K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.2K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

4.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Customizable FDM-based zebrafish larva mold for live imaging.

Biology open·2026
Same author

Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties.

Nature materials·2026
Same author

Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers.

The EMBO journal·2026
Same author

PhotoFiTT: a quantitative framework for assessing phototoxicity in live-cell microscopy experiments.

Nature communications·2025
Same author

Regulation of cell dynamics by rapid integrin transport through the biosynthetic pathway.

The Journal of cell biology·2025
Same author

ADAM10 Knockout from Human Glioblastoma and Colon Cancer Cells Modulates Diverse Signalling Networks and Inhibits Tumour Growth In Vivo.

International journal of molecular sciences·2025
Same journal

Considering internal conflict in the face of natural product biosynthesis and biosynthetic gene cluster evolution.

Essays in biochemistry·2026
Same journal

The plant holobiont: integrating molecular priming and ecological legacies for climate-adaptive immunity.

Essays in biochemistry·2026
Same journal

Bacterial-fungal interactions: connections and consequences.

Essays in biochemistry·2026
Same journal

Invasive plasmids as ecosystem engineers-from mechanism to application.

Essays in biochemistry·2026
Same journal

From early defence priming to lasting memory: developmental and seasonal dynamics in trees.

Essays in biochemistry·2026
Same journal

When context matters: community and environmental context to elicit natural products.

Essays in biochemistry·2026
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

24.2K

Cell matrix adhesion in cell migration.

James R W Conway1, Guillaume Jacquemet1,2

  • 1Turku Bioscience Centre, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland.

Essays in Biochemistry
|August 25, 2019
PubMed
Summary
This summary is machine-generated.

Cell migration relies on integrin adhesion complexes (IACs) that connect cells to their environment. This review explores how IACs regulate cell movement through signaling, mechanosensing, and matrix remodeling.

Keywords:
Cell migrationcell adhesionextracellular matrixintegrins

More Related Videos

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

11.4K
Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

13.0K

Related Experiment Videos

Last Updated: Jan 20, 2026

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

24.2K
Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

11.4K
Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

13.0K

Area of Science:

  • Cell Biology
  • Biophysics

Background:

  • Cell migration is crucial for development, immunity, and healing.
  • Integrins and adhesion complexes mediate cell-environment interactions.
  • Understanding these complexes is key to cell motility.

Purpose of the Study:

  • To review the role of integrin adhesion complexes (IACs) in cell migration.
  • To highlight regulatory mechanisms of IACs.
  • To discuss IACs' impact on extracellular matrix remodeling.

Main Methods:

  • Literature review of cell migration and integrin adhesion complexes.
  • Analysis of intracellular signaling pathways.
  • Examination of mechanosensing and matrix remodeling roles.

Main Results:

  • IACs integrate signals for cell migration.
  • Regulation involves complex intracellular cascades and mechanosensing.
  • IACs actively remodel the extracellular matrix.

Conclusions:

  • Integrin adhesion complexes are central regulators of cell migration.
  • Their function is modulated by intricate signaling and physical cues.
  • IACs are key players in tissue dynamics and repair.