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Updated: Jan 20, 2026

Monitoring Dynamic Changes In Mitochondrial Calcium Levels During Apoptosis Using A Genetically Encoded Calcium Sensor
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Regional citrate anticoagulation and influence of recirculation on ionized calcium levels in the circuit

Anais Degraeve1, Etienne Danse2, Pierre-François Laterre1

  • 1Department of Intensive Care, Cliniques Universitaires Saint-Luc, Avenue Hippocrate, 10, 1200, Brussels, Belgium.

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
|August 25, 2019
PubMed

Insights

Regional citrate anticoagulation in continuous renal replacement therapy (CRRT) can fail due to deep vein thrombosis near the catheter. This caused local citrate overload without systemic effects, necessitating a catheter site change.

Area of Science:

  • Nephrology
  • Intensive Care Medicine
  • Clinical Biochemistry

Background:

  • Regional citrate anticoagulation (RCA) is a common method for anticoagulation during continuous renal replacement therapy (CRRT), particularly in patients with bleeding risks.
  • Close monitoring of RCA is crucial to prevent citrate overload, which can lead to metabolic alkalosis or acidosis.

Keywords:
Continuous renal replacement therapyRecirculationRegional citrate anticoagulation

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