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Paramagnets are materials with unpaired electrons that possess a finite magnetic moment. In the absence of a magnetic field, these moments are randomly oriented, and thus the net moment is zero. Under an external field, a torque acting on the moments tends to align them along the field's direction. However, the random thermal motion of electrons produces a torque opposite to the external field and tries to disorient the moments. These two competing effects align only a few moments along the...
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According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
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Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
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Oxygen Response Index: A Potential OE-MRI-Derived Non-Invasive Biomarker for Assessing Radiation Treatment Efficacy.

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Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
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Biocompatibility of Oxygen-Sensing Paramagnetic Implants.

Dan Tse1, Periannan Kuppusamy2

  • 1Department of Radiology, Geisel School of Medicine, Dartmouth College, 1 Medical Center Drive, Lebanon, NH, 03756, USA.

Cell Biochemistry and Biophysics
|August 25, 2019
PubMed
Summary
This summary is machine-generated.

New oxygen-sensing implants for electron paramagnetic resonance (EPR) oximetry show no cytotoxicity. Studies confirm the biocompatibility of these paramagnetic microcrystal implants and their components for long-term use in subjects.

Keywords:
ApoptosisCell survivalCellular toxicityOxyChipParticulates

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Area of Science:

  • Biomaterials Science
  • Medical Devices
  • Toxicology

Background:

  • Oxygen-sensing implants utilize paramagnetic microcrystals in polymers for electron paramagnetic resonance (EPR) oximetry.
  • These implants are designed for long-term stability in animal models and human subjects.
  • Potential long-term biocompatibility concerns include cytotoxicity from exposed or leached crystalline components.

Purpose of the Study:

  • To evaluate the in vitro cytotoxicity of oxygen-sensing implants and their crystalline components.
  • To assess the biocompatibility of these implants for potential human use.

Main Methods:

  • In vitro cytotoxicity assays were conducted.
  • Apoptosis and cell viability studies were performed on L6 (rat muscle) and AsPC-1 (human pancreatic cancer) cell lines.
  • Evaluated both intact implants and crystalline particulates.

Main Results:

  • Neither intact implants nor their constituent crystalline materials induced cytotoxicity in tested cell lines.
  • No significant apoptosis or reduction in cell viability was observed.
  • The results indicate a lack of adverse cellular response to the implant materials.

Conclusions:

  • The oxygen-sensing implants and their crystalline components demonstrate excellent biocompatibility.
  • These findings support the long-term safety and suitability of these implants for clinical applications in human subjects.
  • The study establishes the safety profile for EPR oximetry devices utilizing these materials.