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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Isolation of Rat Adipose Tissue Mesenchymal Stem Cells for Differentiation into Insulin-producing Cells
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Mesenchymal stem cells in allergic diseases: Current status.

He Li1, Yunzhe Tian1, Lihui Xie1

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Allergology International : Official Journal of the Japanese Society of Allergology
|August 26, 2019
PubMed
Summary

Mesenchymal stem cells (MSCs) show promise for treating allergic diseases like asthma and eczema due to their immune-modulating and tissue-repairing properties. This review explores MSC therapeutic potential, mechanisms, and future research directions for allergy treatment.

Keywords:
Allergic diseaseAsthmaExosomesImmunomodulationMesenchymal stem cells

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Area of Science:

  • Immunology
  • Regenerative Medicine
  • Allergy Research

Background:

  • Allergic diseases (asthma, skin conditions, rhinitis, conjunctivitis) are a significant global health concern.
  • Mesenchymal stem cells (MSCs) possess immunosuppressive and tissue-regenerative capabilities.
  • MSCs are emerging as a potential therapeutic strategy for allergic conditions.

Purpose of the Study:

  • To review the current understanding of Mesenchymal stem cell (MSC)-based therapies for allergic diseases.
  • To elucidate the biological mechanisms underlying the antiallergic effects of MSCs.
  • To discuss challenges and future prospects in MSC research for allergy treatment.

Main Methods:

  • Literature review of preclinical and clinical studies on MSC therapy for allergic diseases.
  • Analysis of the immunomodulatory and regenerative mechanisms of MSCs.
  • Synthesis of findings on therapeutic benefits and antiallergic actions of MSCs.

Main Results:

  • Clinical and preclinical studies confirm the therapeutic benefits of MSCs in various allergic diseases.
  • MSCs exert antiallergic effects through immunosuppression and secretion of bioactive factors.
  • Evidence supports MSCs as a viable treatment option for allergic conditions.

Conclusions:

  • Mesenchymal stem cells (MSCs) represent a promising therapeutic avenue for managing allergic diseases.
  • Further research is needed to overcome challenges and optimize MSC-based treatments.
  • MSC therapy holds significant potential for advancing allergy management and treatment strategies.