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Antibody deficiency testing for primary immunodeficiency: A practical review for the clinician
Rebecca A Marsh1, Jordan S Orange2
1Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio; Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Objective:
To review selected published studies related to the diagnostic evaluation of antibody deficiency.
Data Sources:
Published literature.
Study Selections:
Studies related to the diagnostic evaluation of antibody deficiency and existing recommendations were selected.
Results:
Many primary immunodeficiency diseases include humoral deficiency. Practical tests used in the clinical evaluation of patients for possible antibody deficiency include immunoglobulin measurement, specific antibody titers, and B-cell enumeration and phenotyping.
Conclusion:
Clinically available tests can be used to readily evaluate patients for antibody deficiencies.
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