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The PPM1F gene moderates the association between PTSD and cortical thickness

Danielle R Sullivan1, Filomene G Morrison1, Erika J Wolf1

  • 1National Center for PTSD, VA Boston Healthcare System, Boston, MA, United States; Department of Psychiatry, Boston University School of Medicine, Boston, MA, United States.

Journal of Affective Disorders
|August 26, 2019
PubMed
Summary

Genetic variants in the PPM1F gene influence the relationship between post-traumatic stress disorder (PTSD) symptom severity and prefrontal cortex thickness in veterans. Specific PPM1F single nucleotide polymorphisms (SNPs) are linked to reduced cortical thickness with higher PTSD symptoms.

Keywords:
Cortical thicknessGeneticsMRIPPM1FPTSDPrefrontal cortex

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