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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design

Alistair O'Brien1, Stephen P Andrews2, Asma H Baig1

  • 1Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom.

Bioorganic & Medicinal Chemistry Letters
|August 27, 2019
PubMed

Keywords:
Allosteric antagonistGCGRGLP-1RHTL26119

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