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Updated: Jan 20, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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NSAID associated bilateral renal infarctions: a case report.
Yejoo Jeon1, Jonathan B Lis1, William G Chang1
1Yale School of Medicine, Department of Internal Medicine, Yale University, New Haven, CT, USA.
International Journal of Nephrology and Renovascular Disease
|August 27, 2019
Summary
Non-steroidal anti-inflammatory drugs (NSAIDs) may cause rare renal infarctions by affecting blood flow. This case study suggests NSAID-induced renal injury might be more common than previously believed, especially in vulnerable patients.
Area of Science:
- Nephrology
- Pharmacology
Background:
- Renal infarctions (RIs) result from interrupted renal arterial blood flow.
- RIs are typically considered rare medical events.
- Non-steroidal anti-inflammatory drugs (NSAIDs) can decrease renal perfusion.
Purpose of the Study:
- To investigate the potential link between NSAID use and renal infarction.
- To highlight a possible underrecognized cause of renal injury.
Main Methods:
- Case report of a 37-year-old woman with renal infarction.
- Review of the known physiological effects of NSAIDs on renal hemodynamics.
Main Results:
- The patient's renal infarction was likely caused by the vasoconstrictive effects of NSAIDs.
- NSAIDs' impact on renal perfusion is well-documented, but their role in causing infarction is not widely accepted.
Conclusions:
- NSAID-induced renovascular vasoconstriction may lead to renal infarction, particularly in prostaglandin-dependent states.
- The prevalence of NSAID use suggests this mechanism of renal injury could be more common than currently recognized.
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