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Early Host Interactions That Drive the Dysregulated Response in Sepsis
Steven W Kerrigan1,2,3,4, Tatyana Devine1,3,4, Glenn Fitzpatrick1,2,4
1Cardiovascular Infection Research Group, Royal College of Surgeons in Ireland, Dublin, Ireland.
Frontiers in Immunology
|August 27, 2019
Summary
Sepsis involves a dysregulated host response to infection, where pathogen interactions with endothelial cells and platelets are critical. Understanding these connections may reveal novel sepsis treatments.
Area of Science:
- Immunology
- Infectious Diseases
- Hematology
Background:
- Sepsis is a life-threatening condition characterized by organ dysfunction due to a dysregulated host response to infection.
- Early sepsis progression involves critical interactions between pathogens, endothelial cells, and platelets.
- Existing research highlights molecular interactions between pathogens and both endothelial cells and platelets.
Purpose of the Study:
- To review the compensatory connections between bacteria/viruses and platelets/endothelial cells in sepsis.
- To explore how understanding these interactions can inform novel sepsis treatment strategies.
Main Methods:
- Literature review focusing on molecular interactions in sepsis.
- Analysis of current research on pathogen-endothelial cell and pathogen-platelet interactions.
- Synthesis of information on compensatory mechanisms in sepsis.
Main Results:
- Pathogen engagement with endothelial cells and platelets is a key driver of the host response in sepsis.
- Numerous compensatory connections exist between various pathogens (bacteria, viruses) and host cells (platelets, endothelial cells).
- These complex interactions influence the progression and severity of sepsis.
Conclusions:
- A deeper understanding of pathogen-host cell interactions is crucial for developing effective sepsis therapies.
- Targeting the interplay between pathogens, platelets, and endothelial cells offers potential for novel therapeutic approaches to sepsis.
- Further research into these specific molecular pathways is warranted to combat sepsis effectively.
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