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Updated: Jan 20, 2026

Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
Closure of stage 2 macular hole with a low-dose intravitreal injection of perfluoropropane
Jesús H González-Cortés1, Abraham Olvera-Barrios1, Hugo A Treviño-Rodríguez1
1Departamento de Oftalmología, Hospital Universitario y Facultad de Medicina.
Background:
Idiopathic macular holes (IMH) are common and affect central vision. We demonstrate the effectiveness of 0.2 ml intravitreal perfluoropropane (C3F8) in Stage-2 IMH.
Case:
A 61-year-old woman presented with blurred vision OD. Best-corrected visual acuity (BCVA) was 20/125 OD and 20/20 OS. Biomicroscopy of OD evidenced a Stage-2 IMH. Intravitreal C3F8 was injected and postural measures prescribed. Optical coherence tomography 1 week after revealed posterior vitreous detachment and vitreomacular traction resolution. Full anatomical and functional recovery was achieved at week 4 and remained stable during a 6-month follow-up (BCVA 20/20 OD).
Conclusion:
Intravitreal C3F8 as initial therapy for Stage 2 IMH represents a good alternative to vitrectomy for patients with IMH.
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