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Isolation of Murine Adipose Tissue-derived Microvascular Fragments as Vascularization Units for Tissue Engineering
Published on: April 30, 2017
Visceral adipose tissue normative values in adults from the United States using GE Lunar iDXA
Katie R Hirsch1,2, Malia N M Blue1,2, Eric T Trexler1,2
1Applied Physiology Lab, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Objectives:
To create normative data for visceral adipose tissue (VAT) derived from the GE Lunar iDXA specific to sex and age cohorts for adults in the United States (US).
Methods:
A cross-sectional analysis of 649 adults were evaluated [Mean ± SD (Range): Males: n = 351; Age = 33·2 ± 17·4 years (18-75 years); Body mass index (BMI) = 26·5 ± 5·4 kg·m-2 (17·5-44·2 kg·m-2 ); Females: n = 298; Age = 28·5 ± 14·3 years (18·0-75·0 years); BMI=25·8 ± 6·9 kg·m-2 (17·9-54·8 kg·m-2 )]. From a total body dual-energy X-ray absorptiometry (DXA) scan, VAT mass (kg) and volume (cm3 ) were quantified from the software-delineated region-of-interest. The relationship between VAT and age was evaluated using regression analysis. Separate VAT percentiles were stratified by age range (18-19 years; 20-24 years; 25-50 years; 50+ years) for males and females.
Results:
In both males and females, there was a positive, non-linear relationship between VAT and age (R2 = 0·47-0·49; P<0·0001). In males, the 50th percentile for VAT mass and volume, stratified by age was: 18-19 years (0·18 kg; 185·67 cm3 ), 20-24 years (0·25 kg; 261·21 cm3 ), 25-49 years (0·71 kg; 746·27 cm3 ) and 50+ years (1·62 kg; 1708·36 cm3 ). In females, the 50th percentile for VAT mass and volume, stratified by age was: 18-19 years (0·04 kg; 44·90 cm3 ), 20-24 years (0·06 kg; 59·57 cm3 ), 25-49 years (0·55 kg; 579·28 cm3 ) and 50+ years (1·21 kg; 1284·59 cm3 ).
Conclusion:
These normative values provide a reference for VAT mass and volume in US adults 18-75 years of age obtained using the GE Lunar iDXA. Measures of VAT provide important information about metabolic and cardiovascular health risk beyond that of BMI and per cent body fat.
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