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Clickable cellulosic surfaces for peptide-based bioassays.

Maria Teresa Odinolfi1, Alessandro Romanato1, Greta Bergamaschi1

  • 1Consiglio Nazionale delle Ricerche, Istituto di Chimica del Riconoscimento Molecolare (ICRM), Via Mario Bianco, 9, 20131, Milano, Italy.

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Summary
This summary is machine-generated.

Researchers developed a polymer coating for paper-based sensors to prevent peptide probe loss. This improves diagnostic accuracy for diseases like Zika, enhancing peptide bioassays.

Keywords:
CelluloseClick chemistryImmunodiagnosticsMicroarraysPaper based assaysPeptides

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Area of Science:

  • Bioconjugation Chemistry
  • Materials Science
  • Analytical Chemistry

Background:

  • Peptide-based paper analytics show promise but are limited by nonspecific adsorption of peptides onto cellulose.
  • This adsorption reduces the effectiveness of peptide probes, hindering diagnostic applications.

Purpose of the Study:

  • To develop a polymer-based strategy for creating clickable cellulose surfaces.
  • To enable chemoselective bioconjugation of peptide probes onto these surfaces.
  • To improve the performance of peptide-based paper bioassays.

Main Methods:

  • A polymer-based coating was applied to cellulose substrates to create clickable surfaces.
  • Peptide bioprobes were chemoselectively conjugated to the modified surfaces.
  • The new method was compared to standard adsorption-based immobilization in a Zika virus immunoassay.

Main Results:

  • The clickable cellulose surfaces facilitated efficient peptide bioconjugation.
  • The new immobilization strategy significantly outperformed standard adsorption methods.
  • The polymer coating provided anti-fouling properties, further enhancing assay performance.
  • The method successfully discriminated between Zika-positive individuals and healthy controls.

Conclusions:

  • The developed polymer-based strategy effectively overcomes limitations of peptide adsorption in paper analytics.
  • This approach enables robust peptide bioconjugation and improves anti-fouling properties of cellulosic materials.
  • The strategy holds potential for advancing peptide-based paper bioassays and cellulosic material applications.