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Updated: Jan 20, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Anti-inflammatory glycosides from the roots of Paeonia intermedia C. A. Meyer
Liang Yu1, Ling-Juan Zhu1,2, An-Hua Wang1
1School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Abstract:
Three new phenolic glycosides, intermedia A-C (1-3), one new acyclic alcohol glycoside, intermedia D (4), together with 3 known glycosides (5-7), were isolated from the dried roots of Paeonia intermedia C. A. Meyer. Their structures were established by means of extensive spectroscopic analysis (HRESIMS, NMR). Compound 1 have a rare benzo[1,5]dioxepine skeleton. The bioassay results showed that compound 3 exhibited inhibitory activity against proinflammatory cytokines nitric oxide (NO) secretion in LPS-activated RAW264.7 cells with an IC50 value of 85.76 ± 1.36 μM.
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