Related Experiment Video

Updated: Jan 20, 2026

Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy
09:16

Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy

Published on: September 11, 2015

8.7K

[Immunotherapy in Epidermal Growth Factor Receptor-mutant 
Non-small Cell Lung Cancer]

Xin Wang1, Diansheng Zhong1

  • 1Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|August 28, 2019
PubMed

Insights

Immunotherapy shows promise for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. Further research is needed to optimize treatments and understand the interplay between EGFR mutations, the tumor microenvironment, and immunotherapy response.

Area of Science:

  • Oncology
  • Immunology
  • Genetics

Background:

  • Non-small cell lung cancer (NSCLC) treatment increasingly involves targeted therapy and immunotherapy.
  • Epidermal growth factor receptor (EGFR) mutations are a key focus in NSCLC research.
  • Current understanding of immunotherapy in EGFR-mutant NSCLC requires further development.

Purpose of the Study:

  • To review updated data on immunotherapy for EGFR-mutant NSCLC.
  • To explore the relationship between EGFR mutations, immune microenvironment, and treatment efficacy.
  • To identify areas for optimizing immunotherapy combinations, sequencing, and dosage.

Main Methods:

  • Comprehensive literature review of recent preclinical and clinical studies.
  • Analysis of data concerning programmed cell death protein 1 ligand 1 (PD-L1) expression.
  • Evaluation of tumor mutation burden (TMB) in relation to immunotherapy outcomes.

Main Results:

  • Emerging data suggests potential roles for immunotherapy in EGFR-mutant NSCLC.
  • PD-L1 expression and TMB are critical factors influencing treatment response.
  • Optimization of treatment strategies is essential for improving efficacy.

Conclusions:

  • Immunotherapy represents a developing frontier for EGFR-mutant NSCLC.
  • Clarifying the tumor immune microenvironment is crucial for personalized treatment.
  • Continued research is vital to refine treatment protocols and enhance patient outcomes.
Keywords:
Epidermal growth factor receptorImmunotherapyLung neoplasms

More Related Videos

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells08:28

Validated Immunochemical Assay for Comprehensive Determination of the Human Epidermal Growth Factor Receptor 2 Released from and Bound to Cells

Published on: May 9, 2025

698
Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

15.9K

Related Concept Videos

Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
3.2K
Factors Influencing Microbial Growth: pH01:29

Factors Influencing Microbial Growth: pH

Microorganisms are classified as acidophiles, neutrophiles, or alkaliphiles based on their pH growth preferences, reflecting their adaptations to specific environments. Maintaining a stable intracellular pH is critical for macromolecular stability and enzymatic activity, which can be challenged by external pH variations.Neutrophiles, such as Escherichia coli, grow optimally between pH 5.5 and 8.0. These microorganisms inhabit neutral or slightly acidic environments and employ mechanisms like...
1.1K
Factors Influencing Microbial Growth: Temperature01:27

Factors Influencing Microbial Growth: Temperature

Microorganisms display remarkable adaptations, enabling them to thrive in diverse ecological niches across a wide range of temperatures. Temperature profoundly influences microbial growth by affecting enzymatic activity, membrane fluidity, and other cellular processes.Each microorganism operates within a specific temperature range defined by three cardinal points: minimum, optimum, and maximum. Below the minimum temperature, membranes lose fluidity, halting transport processes. Above the...
1.1K
Factors Influencing Microbial Growth: Osmolarity01:28

Factors Influencing Microbial Growth: Osmolarity

Osmolarity is the measure of solute concentration in a solution. It plays a critical role in determining water availability for organisms. Water moves across semipermeable membranes through osmosis, flowing from regions of lower solute concentration (more dilute) to regions of higher solute concentration (more concentrated).In high-solute environments, microbial cells lose water, leading to dehydration and inhibited growth. The extent to which water is available to microbes in such environments...
750
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.0K