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Quadruple hybridization of quinoline-triazole oligomers
Kai Zhang1, Chunmiao Ma, Ning Li
1Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, P. R. China. ganquan@hust.edu.cn.
Abstract:
A series of quinoline-triazole oligomers and their quadruple helical structures are demonstrated. The helical folding is mainly induced by the intramolecular hydrogen bonds, and solvophobic effects impel the aggregation, causing the quadruplex to be more stable in DMSO than in CDCl3 by four orders of magnitude. As a proof of concept, our studies reveal a tetramerization mechanism in which the single sequences first hybridize to dimers, and then two such dimers further aggregate into a quadruplex.
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