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Falls in Synucleinopathies.

Stephen Joza1, Richard Camicioli1, Fang Ba1

  • 1Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|August 28, 2019
PubMed
Summary
This summary is machine-generated.

Falls are common in Parkinson's disease (PD) and related synucleinopathies due to axial symptoms. This review examines fall risk factors and prevention strategies for these neurological disorders.

Keywords:
Dementia with Lewy bodiesFallsManagementMultiple system atrophyParkinson’s diseasePreventionRisk

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Area of Science:

  • Neurology
  • Neurodegenerative Disorders
  • Movement Disorders

Background:

  • Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are synucleinopathies sharing common pathology.
  • Axial symptoms like gait and balance impairment in parkinsonism are poorly responsive to current therapies, leading to frequent falls.
  • Falls contribute significantly to injury and loss of independence in patients with parkinsonism.

Purpose of the Study:

  • To identify modifiable and non-modifiable risk factors for falls in patients with synucleinopathies.
  • To review and evaluate evidence-based strategies for fall prevention in these neurological conditions.
  • To emphasize the importance of individualized and multifaceted approaches to fall prevention.

Main Methods:

  • Literature review focusing on risk factors for falls in PD, DLB, and MSA.
  • Evaluation of evidence for pharmacological interventions in fall prevention.
  • Assessment of nonpharmacological and surgical approaches for mitigating fall risk.

Main Results:

  • Identified key risk factors contributing to falls in synucleinopathies.
  • Summarized the efficacy of various treatment modalities for fall prevention.
  • Highlighted the need for comprehensive fall risk assessment and tailored interventions.

Conclusions:

  • Falls represent a critical challenge in the management of synucleinopathies.
  • A combination of pharmacological, nonpharmacological, and potentially surgical strategies is necessary for effective fall prevention.
  • Personalized treatment plans are essential for improving outcomes and maintaining independence in patients with parkinsonism.