Pixel Prostate Software as a Reliable Tool in Depicting Spatial Distribution and Determination of the Prostate Cancer...

Area of Science:

• Urology
• Oncology
• Medical Imaging

Background:

• Prostate cancer (PCa) is a leading cause of cancer death in men.
• Limited research exists on the diagnostic and prognostic value of needle biopsy-obtained PCa.
• Accurate assessment of PCa volume and distribution is crucial for effective management.

Purpose of the Study:

• To evaluate the utility of Pixel Prostate software for determining PCa volume and topographic distribution.
• To analyze PCa characteristics using Pixel Prostate software in conjunction with other relevant variables.
• To assess the software's impact on clinical decision-making and biopsy planning.

Main Methods:

• Retrospective analysis of 75 patients' data and postoperative prostate specimens.
• Utilized Pixel Prostate software to determine topographic distribution and cancer volume (PCa).
• Correlated software-derived metrics with preoperative and postoperative pathological findings.

Main Results:

• Mean cancer volume (%VPCa) was 16%, with significant variation.
• Preoperative under-grading of Gleason score occurred in 36% of patients.
• Bilateral PCa detection increased from 51% to 87% postoperatively.
• Preoperative bilateral needle biopsy findings accurately predicted %VPCa > 10% (AUC 0.75).
• %VPCa correlated well with prostate-specific antigen (PSA) and PSA-density.

Conclusions:

• Pixel Prostate software enables precise spatial orientation and volume characterization of PCa.
• Software feedback enhances clinician understanding for improved prostate biopsy planning.
• This tool is valuable for clinical decision-making in managing prostate cancer.