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Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
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Sulthiame add-on therapy for epilepsy.
Rebecca Bresnahan1, Kirsty J Martin-McGill, Philip Milburn-McNulty
1Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Lower Lane, Liverpool, UK, L9 7LJ.
The Cochrane Database of Systematic Reviews
|August 28, 2019
Summary
This review found very limited evidence that sulthiame may help stop seizures in infants with West syndrome when added to other treatments. However, the evidence is unreliable, and more research is needed for epilepsy treatment.
Area of Science:
- Neurology
- Pharmacology
- Clinical Trials
Background:
- Epilepsy affects many, with about 30% not responding to standard antiepileptic drugs.
- Sulthiame is an antiepileptic drug commonly used in Europe and Israel.
- This review summarizes evidence on sulthiame as adjunctive therapy for epilepsy.
Purpose of the Study:
- To evaluate the efficacy and tolerability of sulthiame as add-on therapy for epilepsy.
- To compare sulthiame against placebo or other antiepileptic drugs.
Main Methods:
- Searched multiple databases including CENTRAL, MEDLINE, ClinicalTrials.gov, and WHO ICTRP up to January 2019.
- Included randomized controlled trials of add-on sulthiame in epilepsy patients of any age.
- Assessed outcomes such as seizure frequency reduction, seizure cessation, adverse events, and quality of life.
Main Results:
- One placebo-controlled trial involving 37 infants with West syndrome was included.
- No statistically significant difference in seizure cessation (RR 11.14, P=0.09) or adverse events (RR 0.85, P=0.63) was found.
- Evidence certainty was very low due to study limitations; no data on other outcomes or epilepsy types were available.
Conclusions:
- Sulthiame's potential to cease seizures in West syndrome infants is uncertain due to a small, biased study.
- No conclusions can be drawn regarding adverse effects, quality of life, or seizure frequency reduction.
- Large, multi-center randomized controlled trials are required to establish sulthiame's efficacy and safety in epilepsy treatment.
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