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Preparation of Polyoxometalate-based Photo-responsive Membranes for the Photo-activation of Manganese Oxide Catalysts
Published on: August 7, 2018
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Polyoxometalates in Biomedicine: Update and Overview
Mirjana B Čolović1, Milan Lacković2, Jovana Lalatović3
1Department of Physical Chemistry, "Vinca" Institute of Nuclear Sciences, University of Belgrade, Belgrade 11,000, Serbia.
Current Medicinal Chemistry
|August 28, 2019
Summary
Polyoxometalates (POMs) show diverse biological activities, including anti-viral, anti-bacterial, and anti-tumor effects. Further research is needed to understand their mechanisms and advance clinical applications for diseases like diabetes.
Area of Science:
- Inorganic Chemistry
- Materials Science
- Medicinal Chemistry
Background:
- Polyoxometalates (POMs) are negatively charged metal-oxo clusters with diverse applications.
- POMs exhibit significant biological activities, including antitumor, antimicrobial, and antidiabetic properties.
- Their unique structures and properties make them attractive for biomedical research.
Purpose of the Study:
- To provide a comprehensive overview of recent studies on the biological activities of POMs.
- To review the biomedical applications of POMs as potential therapeutic agents.
- To discuss the putative mechanisms of action and molecular targets of POMs.
Main Methods:
- Literature search conducted using PubMed and Scopus databases.
- Keywords focused on polyoxometalates, biological activities, and biomedical applications.
- Review of peer-reviewed articles on the topic.
Main Results:
- POMs demonstrate promising anti-viral, anti-bacterial, anti-tumor, and anti-diabetic activities.
- This review highlights recent advancements in understanding POMs' biological effects.
- Mechanisms of action and molecular targets are considered for various POM applications.
Conclusions:
- Despite reported biological activities, POMs are not yet in clinical trials for major diseases.
- Further studies are required to elucidate POM mechanisms for targeted therapy and reduced toxicity.
- Biomedical research should focus on solution-stable POMs under physiological conditions.
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