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TERT rs10069690 polymorphism and cancers risk: A meta-analysis
Guisheng He1, Tao Song1, Yazhen Zhang1
1Department of Surgical Oncology, Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan Province, China.
Molecular Genetics & Genomic Medicine
|August 28, 2019
Summary
The TERT rs10069690 gene polymorphism is linked to an increased overall cancer risk. This meta-analysis found it particularly associated with breast, ovarian, lung, thyroid, and renal cell carcinoma, but decreased risk for pancreatic cancer in Europeans.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The telomerase reverse transcriptase (TERT) gene polymorphism rs10069690 (C>T) has been investigated for its association with cancer risk.
- Previous studies have yielded inconclusive results regarding this link.
Purpose of the Study:
- To conduct a comprehensive meta-analysis to precisely estimate the relationship between the TERT rs10069690 polymorphism and cancer risk.
- To explore potential sources of heterogeneity through stratified analyses.
Main Methods:
- A meta-analysis was performed on 45 studies, encompassing 329,035 cancer cases and 730,940 controls.
- Searches were conducted in PubMed, Google Scholar, and Web of Science.
- Stratification by ethnicity, cancer type, control source, sample size, and genotyping methods was employed. Random effects models were used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- The TERT rs10069690 polymorphism was significantly associated with an overall increased cancer risk (OR = 1.09, 95% CI: 1.06-1.12).
- Stratification revealed increased risk for breast, ovarian, lung, thyroid, and renal cell carcinoma (RCC).
- A decreased risk was observed for pancreatic cancer in Europeans (OR = 0.93, 95% CI: 0.87-0.99). No significant association was found for prostate, leukemia, colorectal, or glioma.
Conclusions:
- The TERT rs10069690 polymorphism is suggested as a potential risk factor for various cancers, notably breast, ovarian, lung, thyroid, and RCC.
- Further functional studies are recommended to elucidate the precise role of this polymorphism in the development of cancer.
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