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Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
Pulmonary Hypertension: Brief Review Article
Ahmed Gohar1, Anup Shrestha1, Adam Stys1,2
1Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
Pulmonary hypertension (PH) is a condition where mean pulmonary artery pressure is elevated. This review covers PH classification, diagnosis, and treatment to improve patient outcomes.
Area of Science:
- Cardiology
- Pulmonology
- Medical Research
Background:
- Pulmonary hypertension (PH) is defined by elevated mean pulmonary artery pressure (mPAP) ≥ 25 mmHg at rest.
- Accurate PH prevalence in the U.S. remains undetermined.
- Hemodynamic research has enhanced understanding of pulmonary circulation and right heart function.
Purpose of the Study:
- To review the classification of pulmonary hypertension.
- To outline diagnostic methods for PH.
- To discuss current treatment modalities for PH.
Main Methods:
- Review of existing literature on PH classification, diagnosis, and treatment.
- Analysis of hemodynamic parameters from right heart catheterization.
- Synthesis of current understanding of pulmonary circulation.
Main Results:
- PH is characterized by elevated mPAP, diagnosed via right heart catheterization.
- Advances in understanding PH pathophysiology are ongoing.
- Treatment strategies aim to improve quality of life and reduce mortality.
Conclusions:
- Understanding PH classification and diagnosis is crucial for effective management.
- Improved comprehension of PH aids in developing targeted therapies.
- This review provides a foundation for discussing PH treatment options.
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