Multi-elemental determination in meat samples using multi-isotope calibration strategy by ICP-MS.

Area of Science:

• Analytical Chemistry
• Trace Element Analysis
• Mass Spectrometry

Background:

• Accurate multi-elemental determination is crucial in various scientific fields.
• Traditional calibration methods can be time-consuming and require multiple solutions.
• Developing faster and more efficient calibration strategies is essential for high-throughput analysis.

Purpose of the Study:

• To introduce and validate a novel multi-isotope calibration (MICal) strategy.
• To assess the speed and accuracy of MICal for multi-elemental determination.
• To compare MICal performance against conventional calibration techniques.

Main Methods:

• Developed a calibration strategy using only two solutions: sample/blank and sample/standard.
• Constructed calibration curves using intensity signals from different isotopes.
• Validated the method using standard reference materials (bovine liver and muscle).

Main Results:

• The multi-isotope calibration (MICal) method demonstrated high accuracy.
• Recoveries for MICal ranged from 87% to 113%.
• MICal performance was comparable to the conventional standard additions method (83% to 120% recovery).

Conclusions:

• MICal is a fast, accurate, and efficient calibration strategy for multi-elemental analysis.
• The method simplifies the calibration process by requiring fewer solutions.
• MICal shows significant potential for routine application in elemental determination.