Related Experiment Video
Updated: Jan 20, 2026
08:32
Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
Published on: February 22, 2019
7.5K
Malignant Acanthosis Nigricans: An Indicator of Internal Malignancy
Muhammad Rizwan1, Nadia Iftikhar1, Tariq Sarfraz2
1Department of Dermatology, Pak Emirates Military Hospital, Rawalpindi, Pakistan.
Summary
Malignant acanthosis nigricans, a skin condition, can signal internal cancers. This case highlights its rare association with bile duct cancer, alongside tripe palms and papillomatosis.
Area of Science:
- Dermatology
- Oncology
- Gastroenterology
Background:
- Acanthosis nigricans presents as velvety, hyperpigmented plaques on skin folds.
- Malignant acanthosis nigricans is a paraneoplastic syndrome often linked to gastric cancer.
- Tripe palms, florid cutaneous papillomatosis, and oral lesions suggest internal malignancy.
Observation:
- This report details a rare case of malignant acanthosis nigricans.
- The patient exhibited a combination of tripe palms, florid cutaneous papillomatosis, and oral involvement.
- These dermatological findings were associated with an undifferentiated malignant neoplasm of the hepatic bile ducts.
Findings:
- The case demonstrates a rare presentation of malignant acanthosis nigricans.
- It highlights the association of specific skin manifestations with a rare cancer.
- The findings underscore the importance of dermatological examination in diagnosing internal malignancies.
Implications:
- This case expands the known spectrum of paraneoplastic syndromes.
- It emphasizes the diagnostic value of mucocutaneous findings in oncology.
- Early recognition of these signs may lead to earlier detection of rare cancers.
Related Concept Videos
02:39Indicators
59.7K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
59.7K
02:00Internal Energy
36.5K
The total of all possible kinds of energy present in a substance is called the internal energy (U), sometimes symbolized as E. Suppose a system with initial internal energy, Uinitial, undergoes a change in energy (transfer of work or heat), and the final internal energy of the system is Ufinal. Change in internal energy equals the difference between Ufinal and Uinitial.
36.5K
01:29Internal Energy
6.8K
The internal energy of a thermodynamic system is the sum of the kinetic and potential energies of all the molecules or entities in the system. The kinetic energy of an individual molecule includes contributions due to its rotation and vibration, as well as its translational energy. The potential energy is associated only with the interactions between one molecule and the other molecules of the system. Neither the system's location nor its motion is of any consequence as far as the internal...
6.8K
01:31Internal Receptors
74.3K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.3K
01:29International System of Units
4.8K
The International System of Units, known as the SI system, is a universally accepted measurement system recognized and used worldwide. The SI system is based on a set of three base units considered absolute, and their values do not change with location. These base units are meters, kilograms, and seconds.
Prefixes are used to define both larger and smaller quantities in the SI system. For example, milli, micro, and nano define smaller quantities, while kilo, mega, and giga are used to define...
Prefixes are used to define both larger and smaller quantities in the SI system. For example, milli, micro, and nano define smaller quantities, while kilo, mega, and giga are used to define...
4.8K
01:29Mechanical Ventilation I: Indication and Settings
2.6K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.6K