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Analysis of human cGAS activity and structure.

Wen Zhou1, Aaron T Whiteley1, Philip J Kranzusch2

  • 1Department of Microbiology, Harvard Medical School, Boston, MA, United States; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, United States.

Methods in Enzymology
|August 29, 2019
PubMed
Summary

Cyclic GMP-AMP synthase (cGAS) recognizes aberrant cytosolic DNA, activating the innate immune response. New methods enable studying human cGAS-DNA interactions and structure, aiding therapeutic targeting.

Keywords:
BiochemistryDNA sensingGenetic screeningInnate immunityNucleotidyltransferaseSTINGX-ray crystallographycGAS

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