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Diagnostic Approach to the Patients with Suspected Primary Immunodeficiency
Marzieh Tavakol1,2, Mahnaz Jamee3, Gholamreza Azizi1,4
1Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Background And Objective:
Primary immunodeficiency diseases (PIDs) are a group of more than 350 disorders affecting distinct components of the innate and adaptive immune systems. In this review, the classic and advanced stepwise approach towards the diagnosis of PIDs are simplified and explained in detail.
Results:
Susceptibility to recurrent infections is the main hallmark of almost all PIDs. However, noninfectious complications attributable to immune dysregulation presenting with lymphoproliferative and/or autoimmune disorders are not uncommon. Moreover, PIDs could be associated with misleading presentations including allergic manifestations, enteropathies, and malignancies.
Conclusion:
Timely diagnosis is the most essential element in improving outcome and reducing the morbidity and mortality in PIDs. This wouldn't be possible unless the physicians keep the diagnosis of PID in mind and be sufficiently aware of the approach to these patients.
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