Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Flow Sheet01:17

Flow Sheet

2.6K
Flowsheets are valuable tools in nursing documentation. They enable healthcare professionals to efficiently record and monitor various patient assessments and measurements in a consolidated format.
Here's a closer look at the examples of flowsheets commonly used by nurses:
Graphic Sheet Documentation:
2.6K
Light Acquisition02:16

Light Acquisition

9.4K
In order to produce glucose, plants need to capture sufficient light energy. Many modern plants have evolved leaves specialized for light acquisition. Leaves can be only millimeters in width or tens of meters wide, depending on the environment. Due to competition for sunlight, evolution has driven the evolution of increasingly larger leaves and taller plants, to avoid shading by their neighbors with contaminant elaboration of root architecture and mechanisms to transport water and nutrients.
9.4K
Light as Energy01:35

Light as Energy

95.5K
The energy required to carry out photosynthesis is light— typically electromagnetic radiation from the sun. The range of all possible wavelengths is known as the electromagnetic spectrum.
Photons
A photon is a discrete electromagnetic particle or bundle of energy. Photons are characterized by their frequency, wavelength, and amplitude, similar to the properties of a wave. Waves with higher frequencies transmit more energy and have shorter wavelengths than longer wavelengths that transmit...
95.5K
The Wave Nature of Light02:12

The Wave Nature of Light

60.9K
The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms and was able to demonstrate that white light consists of the individual colors of the rainbow combined together. Newton explained his optics findings in terms of a "corpuscular" view of light, in which light was composed of streams of extremely tiny particles traveling at high speeds according to Newton's laws of motion.
60.9K
Photoreceptors and Plant Responses to Light02:00

Photoreceptors and Plant Responses to Light

28.3K
Light plays a significant role in regulating the growth and development of plants. In addition to providing energy for photosynthesis, light provides other important cues to regulate a range of developmental and physiological responses in plants.
28.3K
Focusing of Light in the Eye01:16

Focusing of Light in the Eye

5.5K
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contact-mode fluorescence imaging for multi-regional assessment of conjunctival goblet cells in humans.

The ocular surface·2026
Same author

Interferon Regulatory Factor 3 as a Mediator and Therapeutic Target in Innate Immune-Driven Corneal Stromal Inflammation and Opacity.

Investigative ophthalmology & visual science·2026
Same author

High-resolution high-contrast in vivo phase imaging of corneal nerves and immune cells in mice.

The ocular surface·2026
Same author

Rapid axially scanned and de-scanned line-scan confocal microscopy with a tunable acoustic gradient index of refraction lens for high-speed volumetric <i>in vivo</i> imaging.

Neurophotonics·2025
Same author

Oblique Light Sheet Fluorescence Microscopy With Surface Tracking for High-Speed Large-Area Imaging of Conjunctival Goblet Cells.

IEEE transactions on medical imaging·2025
Same author

Efferocytosis by Macrophages Attenuates Inflammatory Responses Following Ultraviolet B-Induced Apoptosis in Corneal Stromal Cells.

Investigative ophthalmology & visual science·2025
Same journal

Multi-Scale convolutional neural networks integrated with self-attention for motor imagery EEG decoding.

Biomedical engineering letters·2026
Same journal

Low-power analog and mixed-signal circuit techniques for next-generation miniature implantable neural interface systems.

Biomedical engineering letters·2026
Same journal

Advances in semiconductor materials and device architectures for biomedical systems: a mini review.

Biomedical engineering letters·2026
Same journal

A Multi-perception fusion using shared-control method for brain-mobile robot.

Biomedical engineering letters·2026
Same journal

SSA-DCNet: a cross-session MI-EEG classification network based on deformable convolution and spatial-shift attention.

Biomedical engineering letters·2026
Same journal

Advanced silicon nanomembrane based bioelectronics for flexible and stretchable implantable systems.

Biomedical engineering letters·2026
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

Imaging the Aging Cochlea with Light-Sheet Fluorescence Microscopy
05:27

Imaging the Aging Cochlea with Light-Sheet Fluorescence Microscopy

Published on: September 28, 2022

2.8K

Light sheet microscopy for histopathology applications.

Praveen Kumar Poola1, Muhammad Imran Afzal1, Youngseung Yoo1

  • 11Department of Biomedical Science and Engineering (BMSE), Gwangju Institute of Science and Technology (GIST), Gwangju, 61005 Republic of Korea.

Biomedical Engineering Letters
|August 29, 2019
PubMed
Summary
This summary is machine-generated.

Light sheet microscopy (LSM) offers high-speed, low-phototoxicity imaging for tissue samples. This advanced technique shows promise for rapid 3D diagnosis of human biopsies, potentially replacing traditional methods.

Keywords:
3D imagingClinical applicationHistopathologyLight sheet microscopyTissue clearing

More Related Videos

Multilayer Mounting for Long-term Light Sheet Microscopy of Zebrafish
07:28

Multilayer Mounting for Long-term Light Sheet Microscopy of Zebrafish

Published on: February 27, 2014

19.5K
Light-sheet Fluorescence Microscopy for the Study of the Murine Heart
08:42

Light-sheet Fluorescence Microscopy for the Study of the Murine Heart

Published on: September 15, 2018

9.7K

Related Experiment Videos

Last Updated: Jan 20, 2026

Imaging the Aging Cochlea with Light-Sheet Fluorescence Microscopy
05:27

Imaging the Aging Cochlea with Light-Sheet Fluorescence Microscopy

Published on: September 28, 2022

2.8K
Multilayer Mounting for Long-term Light Sheet Microscopy of Zebrafish
07:28

Multilayer Mounting for Long-term Light Sheet Microscopy of Zebrafish

Published on: February 27, 2014

19.5K
Light-sheet Fluorescence Microscopy for the Study of the Murine Heart
08:42

Light-sheet Fluorescence Microscopy for the Study of the Murine Heart

Published on: September 15, 2018

9.7K

Area of Science:

  • Biomedical imaging
  • Optical microscopy
  • Histopathology

Background:

  • Light sheet microscopy (LSM) is an optical imaging technique utilizing plane illumination for optical sectioning and volumetric imaging.
  • LSM is adaptable for diverse applications including cell biology, embryology, and in vivo live imaging.
  • The decoupling of illumination and detection in LSM allows for high-speed, large field-of-view imaging with reduced photobleaching and phototoxicity.

Purpose of the Study:

  • To review emerging biomedical applications of Light Sheet Microscopy (LSM) specifically for human tissue samples.
  • To highlight the potential of LSM to replace conventional histopathological procedures.
  • To demonstrate LSM's rapid diagnostic capabilities in human histopathology.

Main Methods:

  • Review of Light Sheet Microscopy (LSM) technology from its inception to advanced applications.
  • Focus on human histopathological imaging applications of LSM.
  • Comparison of LSM's diagnostic speed with conventional histopathological procedures.

Main Results:

  • LSM's unique characteristics are well-suited for tissue imaging, offering advantages over traditional methods.
  • LSM demonstrates rapid diagnostic ability in human histopathological imaging.
  • The technology has evolved significantly, with advanced capabilities for biomedical applications.

Conclusions:

  • Light Sheet Microscopy (LSM) presents a promising alternative to conventional histopathological procedures.
  • LSM's speed and imaging quality make it suitable for assessing human biopsies.
  • LSM is anticipated to become a valuable tool for three-dimensional imaging in clinical diagnostics in the near future.