Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reversible reproductive dysfunction in men with obstructive sleep apnoea.

J D Santamaria1, J C Prior, J A Fleetham

  • 1Department of Medicine, University of British Columbia, Vancouver, Canada.

Clinical Endocrinology
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Critical Care Outcome Prediction Equation (COPE) model, version 7" [Crit Care Resusc 27 (4) (2025) 100131].

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine·2026
Same author

Lack of evidence that progesterone in ovulatory cycles causes breast cancer.

Climacteric : the journal of the International Menopause Society·2023
Same author

Osteoporotic vertebral fracture (OVF): diagnosis requires an informed observer.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

The diagnosis of osteoporotic vertebral fractures redux.

Clinical radiology·2021
Same author

Where's the break? Critique of radiographic vertebral fracture diagnostic methods.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Simulated effects of early menopausal bone mineral density preservation on long-term fracture risk: a feasibility study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same journal

Supraphysiological Glucocorticoid Doses and Pitfalls of Annual Biomarker Monitoring in Adults With CAH.

Clinical endocrinology·2026
Same journal

Subacute Thyroiditis in Denmark: A Nationwide Study of 1763 Cases.

Clinical endocrinology·2026
Same journal

Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome.

Clinical endocrinology·2026
Same journal

Regarding Non-Classical Presentations of Rare Hereditary Hypoparathyroidism: A Case Series of CASR, GNA11, and GATA3 Mutations in Parathyroidology.

Clinical endocrinology·2026
Same journal

Dual Metabolic Burden of Polyendocrine Metabolic Ovarian Syndrome (PMOS) and Gestational Diabetes in Pregnancy: Impact on Neonatal Anthropometry: Insights From the Born in Bradford Cohort.

Clinical endocrinology·2026
Same journal

Preoperative CALLY Index for Identifying Atypical Parathyroid Tumors.

Clinical endocrinology·2026
See all related articles

Obstructive sleep apnea (OSA) in men is linked to lower testosterone and reduced sexual function. Treatment for OSA reversed these effects, improving sexual health and testosterone levels.

Area of Science:

  • Reproductive Endocrinology
  • Sleep Medicine
  • Andrology

Background:

  • Obstructive sleep apnea (OSA) is increasingly recognized for its systemic health impacts.
  • Male sexual dysfunction is a potential, yet often overlooked, consequence of OSA.
  • The underlying mechanisms linking OSA to reproductive dysfunction require further elucidation.

Purpose of the Study:

  • To investigate the relationship between obstructive sleep apnea (OSA) and male sexual function.
  • To assess serum testosterone levels in men with and without OSA.
  • To evaluate the impact of surgical treatment for OSA on sexual function and reproductive hormones.

Main Methods:

  • A case series comparing 15 men with OSA to 9 snorers without OSA undergoing sleep studies.

Related Experiment Videos

  • Measurement of serum testosterone (T) and gonadotrophins (LH, FSH, PRL).
  • A prospective trial of uvulopalatopharyngoplasty (UPP) for OSA, assessing changes in T and sexual function post-surgery.

    • Main Results:

    • Men with OSA had significantly lower serum testosterone (9.18 +/- 0.92 nmol/l) compared to controls (11.55 +/- 0.90 nmol/l).
    • Serum T correlated with minimum nocturnal oxygen saturation (Min SaO2) but not age or BMI.
    • UPP surgery in OSA patients led to increased T levels (13.31 to 16.59 nmol/l) and improved sexual function in 7/7 men reporting prior issues.

    Conclusions:

    • Obstructive sleep apnea (OSA) is associated with reversible hypogonadism and sexual dysfunction in men.
    • The hypothalamic-pituitary reproductive axis appears affected by OSA.
    • Uvulopalatopharyngoplasty (UPP) can effectively restore sexual function and normalize testosterone levels in men with OSA.