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Updated: Jan 20, 2026
Biodistribution of Nano Carriers: Imaging using SEM and EDS
Published on: April 30, 2023
Revealing Drug Self-Associations into Nano-Entities
Marwa M Dlim1, Fatma S Shahout1, Marwa K Khabir1
1INRS, Institut Armand-Frappier, Université du Québec, 531, boul. des Prairies, Laval, Québec H7V 1B7, Canada.
Abstract:
The aqueous properties of the drugs Sorafenib, Lapatinib, Gefitinib, Fulvestrant, and Clofazimine were explored to monitor their tendency to self-associate. A combination of nuclear magnetic resonance, dynamics light scattering, and electron and confocal microscopies found that they tended to form large nano-entities having distinct types and sizes and were capable of entering cells. The combination of strategies employed serves to detect and reveal nano-entities along with their three-state equilibria and behaviors in buffers, media, and cells.
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