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Updated: Jan 20, 2026
Chemical Reactions in Aqueous Solutions
K2S2O8-Mediated Hydroxyalkylation of Benzothiazoles with Alcohols in Aqueous Solution
Wen-Xiu Xu1, Xiao-Qiang Dai1, Jian-Quan Weng1
1College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
Abstract:
The K2S2O8-mediated hydroxyalkylation of 2H-benzothiazoles with aliphatic alcohols in aqueous solution was described. The mild and convenient protocol generated a series of hydroxyalkylated benzothiazoles in moderate to good yields. Besides, benzimidazole and ethers were also compatible in this reaction, leading to corresponding C2 ether-substituted heteroarenes.
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