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Updated: Jan 20, 2026

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
Three-Component One-Pot Synthesis of Highly Functionalized Bis-Indole Derivatives
Xue-Bing Chen1, Sheng-Li Xiong1, Zhi-Xu Xie1
1School of Science, Honghe University, Mengzi, 661100 Yunnan, P. R. China.
Abstract:
In this study, we detail the development of a concise and efficient three-component protocol for the regioselective synthesis of highly functionalized bis-indoles through a one-pot, two-step sequential process starting from enaminones 1, indoles 2, and acenaphthylene-1,2-dione 3 that is catalyzed by piperidine and p-methyl benzenesulfonic acid. This protocol has several advantages including simplicity of experimental operation, high efficiency of bond formation, ready availability and low cost of starting materials, environmentally benign conditions, and target molecular diversity.
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