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Updated: Jan 20, 2026
Catalysis: Homogenious and Heterogeneous Catalysis
Tandem arylation and regioselective allylic etherification of 2,3-allenol via Pd/B cooperative catalysis
Hongfang Li1, Tao Li2, Yu Jen Hsueh2
1Key Laboratory for Organism Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, and Department of Chemistry, College of Science, Yanbian University, 977 Gongyuan Road, Yanji, Jilin 133002, P. R. China. wuxue@ybu.edu.cn and School of Chemistry and Chemical Engineering, and Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong32 University, 800 Dongchuan Road, Shanghai 200240, P. R. China. yjian@sjtu.edu.cn.
Abstract:
An efficient method for the construction of arylated allylic ethers was developed via three-component tandem arylation and allylic etherification of 2,3-allenol with aryl iodides and alcohols. In the cooperative catalytic system of a palladium complex and triethylborane, the process allows rapid access to functionalized 1-arylvinylated 1,2-diol derivatives in good to high yields with complete branch-selectivities. The synthetic utility of the present process was demonstrated by the late-stage functionalization of a drug molecule, the gram-scale synthesis and the elaboration of the products.
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