Protein Network Analysis of the Fifth Chromosome of Zebrafish

In the past 20 years, zebrafish has gradually become an important animal model for studying the function of human genes. At the same time, identification of zebrafish reference genome sequences and >10,000 protein-coding genes indicates that they are at least 75% homologous to human genes, further validating its utility as a research model for growth and developments (GDs). However, the molecular mechanism of zebrafish GDs has almost no molecular interactions, so a protein-protein interaction (PPI) network is highly desirable. The project extracted 58 genes on the fifth chromosome of the model organism, and studied and modeled its GDs mechanisms, which encompassed 296 interactions between the 58 proteins involved in GDs. This includes not only accurate predictions of PPI but also those molecular interactions collected from the literature and experimentally derived. These molecules then interact, modularize, look for central genes, analyze, and predict their GDs processes, and hope to help scholars study the process of GDs, providing hypotheses and help.