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Preclinical dose verification using a 3D printed mouse phantom for radiobiology experiments.

Nolan Esplen1, François Therriault-Proulx2, Luc Beaulieu2,3

  • 1Department of Physics and Astronomy, University of Victoria, Victoria, BC, V8P 5C2, Canada.

Medical Physics
|August 29, 2019
PubMed
Summary

This study demonstrates that a 3D printed mouse phantom accurately verifies preclinical radiotherapy doses. This cost-effective phantom improves dosimetry for radiobiology research.

Keywords:
3D printingdosimetryphantom

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Area of Science:

  • Medical Physics
  • Radiotherapy Dosimetry
  • Preclinical Research

Background:

  • Preclinical radiotherapy dose verification faces challenges due to non-standardized techniques and small-field dosimetry difficulties.
  • Realistic small-animal phantoms are crucial for improving dosimetric accuracy in radiobiological studies.
  • Three-dimensional (3D) printing enhances phantom conformity to small animals, improving representational accuracy.

Purpose of the Study:

  • To evaluate a fully 3D printed mouse phantom for preclinical treatment verification.
  • To assess the phantom's utility for various anatomical targets in sophisticated therapies.
  • To validate dosimetry accuracy and precision in small-animal radiotherapy research.

Main Methods:

  • Anatomically realistic mouse phantom 3D printed from microCT data.
  • Integration of radiochromic film and plastic scintillator dosimeters (PSD) within the phantom.
  • Monte Carlo (MC) modeling used to verify experimental dose measurements from PSD and film.

Main Results:

  • MC-calculated and measured doses achieved a 5% agreement goal for radiobiology experiments.
  • 2D film and MC dose distributions showed agreement within 2.3% for lateral profiles.
  • PSD point-dose measurements exhibited a maximum deviation of 3.2% across different treatment sites.

Conclusions:

  • 3D printed phantoms are effective for accurate dose estimation in preclinical radiotherapy.
  • The phantom facilitates precise dosimetry and reduces costs in radiobiology experiments.
  • This tool is valuable for pretreatment dose verification in small-animal studies.