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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...

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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...

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Social Proof and Customer Reviews

A phenomenon known as social proof significantly influences consumer behavior by prompting individuals to mimic the actions of others under the assumption that these actions are correct. This psychological trigger is especially potent in the context of online shopping, where customers rely on the experiences and opinions of others to guide their purchasing decisions. Social proof manifests in various forms, each serving to enhance a brand's credibility and sway potential buyers.
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Point-of-Care Ultrasound: A Review of Ultrasound Parameters for Predicting Difficult Airways

Point-of-Care Ultrasound: A Review of Ultrasound Parameters for Predicting Difficult Airways

A point-of-care ultrasound (POCUS) is a simple, non-invasive, and portable tool that enables dynamic airway assessment. Several studies have attempted to determine the role of ultrasound parameters as an adjunct to clinical examination in predicting difficult...

Equipment Setup and Artifact Removal for Simultaneous Electroencephalogram and Functional Magnetic Resonance Imaging for Clinical Review in Epilepsy

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Updated: Jan 20, 2026

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Sarecycline Review.

Wasim Haidari¹, Raquel Bruinsma¹, Jesus Alberto Cardenas-de la Garza¹

¹Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

The Annals of Pharmacotherapy

|August 30, 2019

Summary

This summary is machine-generated.

Sarecycline, a new oral tetracycline antibiotic, effectively reduces inflammatory acne lesions. This well-tolerated medication offers targeted antimicrobial activity, potentially lowering antibiotic resistance risks for moderate to severe acne patients.

Keywords:

acne adverse drug reactions antibiotic antibiotic resistance microbiological profile pregnancy/drug effects tetracyclines

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Area of Science:

Dermatology
Pharmacology
Microbiology

Background:

Sarecycline is a novel oral tetracycline antibiotic recently approved by the US FDA.
Acne vulgaris is a common skin condition with various treatment options, including antibiotics.

Purpose of the Study:

To evaluate clinical trial data for sarecycline in acne treatment.
To review sarecycline's pharmacology and its clinical application.
To assess sarecycline's efficacy and safety profile.

Main Methods:

Systematic literature review of MEDLINE, EMBASE, and ClinicalTrials.gov.
Inclusion of English articles from January 2000 to April 2019.
Evaluation of clinical trials, pharmacology, safety, and microbiological data.

Main Results:

Phase 3 trials (SC1401, SC1402) showed significant reduction in facial inflammatory lesions with sarecycline compared to placebo (P < 0.01).
Mean percentage change in lesion count was significantly higher in the sarecycline group.
Sarecycline demonstrated good tolerability and targeted antimicrobial activity.

Conclusions:

Sarecycline (1.5-mg/kg dose) is effective in reducing inflammatory acne lesions.
The drug is well-tolerated and may help mitigate antibiotic resistance.
Sarecycline represents a potentially valuable new treatment for moderate to severe acne.