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Related Experiment Video

Updated: Jan 20, 2026

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

Published on: May 31, 2018

Promise, progress, and problems in whole disc tissue engineering.

Sarah E Gullbrand^1,2, Lachlan J Smith^1,2,3, Harvey E Smith^1,2,3

¹Translational Musculoskeletal Research Center Corporal Michael J. Crescenz VA Medical Center Philadelphia Pennsylvania.

|August 30, 2019

Summary

This summary is machine-generated.

Tissue engineering offers a promising alternative to fusion for treating degenerative disc disease. However, challenges like construct size and cell sourcing must be overcome for clinical application of engineered spinal discs.

Keywords:

animal models biomaterials biomechanics disc degeneration mesenchymal stem cells

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Published on: August 30, 2007

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Last Updated: Jan 20, 2026

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Published on: February 10, 2020

Experimental Approaches to Tissue Engineering

Experimental Approaches to Tissue Engineering

Published on: August 30, 2007

Area of Science:

Regenerative Medicine
Biomaterials Science
Orthopedic Surgery

Background:

Intervertebral disc degeneration is a major cause of back and neck pain.
Tissue-engineered disc replacement is a potential alternative to fusion and arthroplasty.

Purpose of the Study:

To review the clinical need for disc tissue engineering.
To summarize the current state of whole disc tissue engineering.
To identify challenges hindering clinical translation.

Main Methods:

Review of current literature on intervertebral disc tissue engineering.
Analysis of in vitro and in vivo studies of engineered disc constructs.
Identification of key barriers to clinical application.

Main Results:

Significant progress in whole disc tissue engineering designs over the past decade.
Various innovative constructs have been developed and tested.
Key challenges include construct size, cell source, culture methods, and animal models.

Conclusions:

Tissue engineering holds promise for treating end-stage disc degeneration.
Overcoming current barriers is crucial for successful clinical translation.
Future research should focus on addressing identified challenges for engineered disc therapies.