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Pooled CRISPR-Based Genetic Screens in Mammalian Cells
09:05

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

Reply to "CRISPR screens are feasible in TP53 wild-type cells"

Emma Haapaniemi1, Sandeep Botla1, Jenna Persson1,2

  • 1Karolinska Institutet, Stockholm, Sweden.

Molecular Systems Biology
|August 30, 2019
PubMed

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Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...