Related Experiment Video
Updated: Jan 20, 2026
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Efficacy and safety of a capsule endoscope delivery device in children
Itaru Iwama1, Hirotaka Shimizu2, Ryusuke Nambu1
1Division of Gastroenterology and Hepatology, Saitama Children's Medical Center, Saitama.
Insights
The AdvanCE capsule endoscope delivery device is safe and effective for pediatric patients in Japan, enabling complete small intestine examinations. Mild adverse events were observed but were manageable.
Area of Science:
- Pediatric Gastroenterology
- Medical Device Technology
- Diagnostic Endoscopy
Background:
- Swallowing capsule endoscopes can be challenging for pediatric patients.
- The AdvanCE device offers a potential solution for capsule endoscope delivery in children.
- Limited data exists on its use in the Japanese pediatric population.
Purpose of the Study:
- To evaluate the efficacy and safety of the AdvanCE capsule endoscope delivery device in children.
- To identify factors influencing successful small bowel capsule endoscope (SBCE) insertion and examination completion.
- To assess adverse events and technical issues associated with the AdvanCE device in pediatric patients.
Main Methods:
- A multicenter, cross-sectional study analyzed 183 SBCE insertions using AdvanCE in 154 patients under 18 years old.
- Data collected from 2013-2017 included device success, examination completeness, transit time, and adverse events.
- Statistical analyses identified factors affecting outcomes, including the use of patency capsules and anesthesia.
Main Results:
- AdvanCE successfully delivered SBCEs in 180 cases (98.3%), with 90% reaching the duodenum.
- Complete small intestine examination was achieved in 89% of patients, yielding diagnostic findings in 63%.
- Mild adverse events occurred in 35% of patients, associated with anesthesia and technical issues, but no severe events were reported.
Conclusions:
- The AdvanCE capsule endoscope delivery device is well-tolerated and effective for pediatric use in Japan.
- It facilitates successful small bowel examinations in children, aiding diagnosis and treatment planning.
- Further research may explore optimizing its use to minimize mild adverse events.
Objectives:
This multicenter, cross-sectional study aimed to elucidate the efficacy and safety of the AdvanCE capsule endoscope delivery device for children in Japan.
Methods:
The present study analyzed 183 cases of small bowel capsule endoscope (SBCE) insertion performed using the AdvanCE in 154 patients aged less than 18 years at participating institutions between 2013 and 2017. Statistical analyses were conducted to identify factors contributing to the completion rate for the entire small intestine examination, small intestine transit time, adverse events and technical issues.
Results:
The commonest reason for using the AdvanCE was the patient's inability to swallow the SBCE, which was attributed to young age. SBCE was successfully delivered into the stomach or duodenum in 180 cases and was placed in the duodenum in 90% patients. In 89% patients, the entire small intestine was completely examined, and in 63% patients, findings leading to a new diagnosis or involving changing or maintaining the treatment strategy were obtained. No severe adverse events were observed; however, mild adverse events were observed in 35% patients. No factors considerably contributed to the completion rate for the entire small intestine examination or small intestine transit time and onset of technical issues. The factors that contributed to mild adverse events included intravenous anesthesia, technical issue, and absence of prior insertion of a patency capsule using the AdvanCE.
Conclusion:
The AdvanCE is well tolerated and effective for children.
Related Concept Videos
04:53A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
09:01Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
01:28Endoscopic Procedures III: Video Capsule Endoscopy
02:30Endoscopic Approach for Colloid Cyst Resection
05:56Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases
05:28A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System