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Updated: Jan 20, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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Development of Novel Irreversible Pyruvate Kinase M2 Inhibitors

I-Shan Hsieh1, Balraj Gopula1,2, Chi-Chi Chou1

  • 1Institute of Biological Chemistry , Academia Sinica , Taipei 11529 , Taiwan.

Journal of Medicinal Chemistry
|August 30, 2019
PubMed
Summary

Researchers developed a novel irreversible inhibitor, compound 1, targeting pyruvate kinase M2 (PKM2) to suppress cancer growth. This compound effectively reduced tumor growth in mice without toxicity, showing promise for new cancer therapies.

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