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Updated: Jan 20, 2026

Generation of a Murine Model with a Central Nervous System Infection
Rickettsial infections of the central nervous system
Zuzana Sekeyová1, Monika Danchenko1, Peter Filipčík2
1Institute of Virology, Slovak Academy of Sciences, Dubravska cesta, Bratislava, Slovakia.
Abstract:
As a result of migrations and globalization, people may face a possible increase in the incidence of central nervous system rickettsial infections (CNS R). These diseases, caused by Rickettsia species and transmitted to humans by arthropod bites, are putatively lethal. However, the diagnosis of CNS R is challenging and often delayed due to their nonspecific clinical presentation and the strict intracellular nature of rickettsiae. Furthermore, transfer of rickettsiae to the brain parenchyma is not yet understood. The aim of this review is to analyze and summarize the features and correlated findings of CNS R in order to focus attention on these intriguing but frequently neglected illnesses. We also incorporated data on CNS infections caused by Rickettsia-related microorganisms.
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