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Updated: Jan 20, 2026

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Standardization of I-124 by three liquid scintillation-based methods.

D E Bergeron1, J T Cessna1, R Fitzgerald1

  • 1Radiation Physics Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899-8462, USA.

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
|August 30, 2019
PubMed
Summary
This summary is machine-generated.

This study standardized Iodine-124 activity using advanced liquid scintillation counting methods. The results confirm previous measurements and identify an error in Fluorine-18 calibration settings used in radionuclide calibrators.

Keywords:
AnticoincidenceDose calibratorFluorine-18Iodine-124Liquid scintillation countingMonte CarloPositron emission tomographyQuantitative imaging

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Area of Science:

  • Nuclear Physics
  • Radiochemistry
  • Metrology

Background:

  • Accurate activity standardization is crucial for nuclear medicine and research.
  • Existing methods for Iodine-124 standardization require validation and refinement.
  • Radionuclide calibrator performance can be affected by calibration settings.

Purpose of the Study:

  • To standardize the activity of an Iodine-124 solution using multiple liquid scintillation counting techniques.
  • To validate the standardization results against previous measurements.
  • To determine and explain discrepancies in radionuclide calibrator settings, particularly for Fluorine-18.

Main Methods:

  • Activity standardization of Iodine-124 using 4πβ(LS)-γ(NaI) live-timed anticoincidence (LTAC) counting.
  • Confirmatory measurements utilizing triple-to-double coincidence ratio (TDCR) and CIEMAT-NIST efficiency tracing (CNET) liquid scintillation counting.
  • Determination and analysis of calibration settings for radionuclide calibrators.

Main Results:

  • The Iodine-124 activity standardized by LTAC counting agreed with previous measurements within stated uncertainties.
  • Confirmatory measurements using TDCR and CNET supported the LTAC-based standard.
  • A discrepancy in literature values for Fluorine-18 calibration was identified and attributed to an erroneous setting.

Conclusions:

  • The developed LTAC method provides a reliable standard for Iodine-124 activity.
  • The findings highlight the importance of accurate calibration settings for radionuclide calibrators.
  • An error in Fluorine-18 calibration methodology was identified and explained, improving future measurements.