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Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
Published on: January 31, 2025
Systemic Therapies for Advanced Melanoma
Leonora Bomar1, Aditi Senithilnathan1, Christine Ahn1
1Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Abstract:
The incidence of metastatic melanoma continues to increase each decade. Although surgical treatment is often curative for localized stage I and stage II disease, the median survival for patients with distant metastases is less than 1 year. The last 2 decades have witnessed a breakthrough in therapeutic options with the development of immune checkpoint inhibitors, small molecule targeted therapy, and oncolytic viral therapy. This article provides an overview of the treatment options available for advanced melanoma, including chemotherapy, targeted therapy, immunotherapy, interleukin-2, and oncolytic viral agents.
Insights
Metastatic melanoma incidence is rising, with poor survival for advanced cases. Recent breakthroughs offer new treatment options like immunotherapy and targeted therapy for better outcomes.
Area of Science:
- Oncology
- Dermatology
- Immunology
Background:
- Metastatic melanoma incidence is increasing globally.
- Current treatments for localized melanoma are effective, but advanced disease survival remains poor.
Purpose of the Study:
- To provide an overview of current treatment options for advanced melanoma.
- To highlight recent therapeutic advancements in melanoma treatment.
Main Methods:
- Review of existing literature on melanoma treatment.
- Analysis of therapeutic options including chemotherapy, targeted therapy, immunotherapy, and oncolytic viral agents.
Main Results:
- Significant progress in therapeutic options over the last two decades.
- Emergence of immune checkpoint inhibitors, small molecule targeted therapy, and oncolytic viral therapy.
Conclusions:
- Advanced melanoma treatment has evolved significantly.
- New therapies offer improved outcomes for patients with metastatic melanoma.
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