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Published on: October 17, 2012

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Pediatric cancer, posttraumatic stress and fear-related neural circuitry

Hilary A Marusak1,2, Felicity W Harper2,3, Jeffrey W Taub4,5

  • 1Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, MI 48201, USA.

International Journal of Hematologic Oncology
|August 31, 2019
PubMed

Insights

Pediatric cancer survivors may experience posttraumatic stress symptoms (PTSS) linked to neurobiological changes. Further research is needed to understand these effects and identify effective interventions for childhood cancer patients.

Area of Science:

  • Neuroscience
  • Pediatric Oncology
  • Psychology

Background:

  • Pediatric cancer survivors are at risk for posttraumatic stress symptoms (PTSS).
  • Understanding the neurobiological underpinnings of PTSS in this population is crucial for developing targeted interventions.
  • Existing research on PTSS neurobiology primarily focuses on non-cancer populations.

Purpose of the Study:

  • To review the neurobiological effects of pediatric cancer-related PTSS.
  • To compare PTSS prevalence and predictors in childhood cancer survivors versus typically developing children.
  • To identify gaps in current research and propose a framework for future studies.

Main Methods:

  • Literature review of studies on childhood cancer-related PTSS prevalence and predictors.
  • Review of neuroimaging studies on PTSS in noncancer populations.
  • Examination of existing neuroimaging research in childhood cancer and PTSS.

Main Results:

  • Childhood cancer survivors exhibit PTSS, with varying prevalence and predictors.
  • Neuroimaging studies in noncancer populations implicate specific brain regions in PTSS.
  • Limited neuroimaging data exists specifically for pediatric cancer-related PTSS.

Conclusions:

  • Further research integrating neuroimaging with clinical and demographic data is essential.
  • Understanding the neurobiological mechanisms of cancer-related PTSS can inform clinical care.
  • A comprehensive framework is proposed to guide future investigations into pediatric cancer-related PTSS.

Keywords:
acute lymphoblastic leukemiaamygdalaanterior cingulate cortexchildhood cancerchildhood leukemiahippocampusneural developmentneuroimagingposttraumatic stress disorderprefrontal cortex

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